Self-indulgence in appetite can lead to extreme physical and social degradation, operating as both a moral failing and a physical disease.

Original passage

Among the victims of intemperance are men of all classes and all professions. Men of high station, of eminent talents, of great attainments, have yielded to the indulgence of appetite until they are helpless to resist temptation. Some of them who were once in the possession of wealth are without home, without friends, in suffering, misery, disease, and degradation. They have lost their self-control. Unless a helping hand is held out to them, they will sink lower and lower. With these, self-indulgence is not only a moral sin, but a physical disease.