"righteousness aroused the anger of Manasseh and his associates in authority, who endeavored to establish themselves in evil-doing by silencing every voice of disapproval. “Manasseh shed innocent blood very much, till he had filled Jerusalem from one end to another.” 2 Kings 21:16 . PK 381.2"
"Moreover Manasseh shed innocent blood very much, till he had filled Jerusalem from one end to another; beside his sin wherewith he made Judah to sin, in doing that which was evil in the sight of the Lord."
Ellen White directly references 2 Kings 21:16 in this passage.